Analysis Of The K-ras Gene Mutation In The Ovarian Serous Borderline Tumor And Malignancy

Obsjective It has been reported that the K-ras gene mutation has a significant effect on tumorigenesis and development of human tumors, including ovarian tumors. Based on our previous results about the mutation of the k-ras gene in ovarian serous and mucinous borderline tumors, it indicated that the K-ras gene mutation patterns in mucinous tumors were similar to those of other studies with the exception of those in ovarian serous tumors. In order to further investigate about the correlation between the K-ras gene mutation and ovarian serous tumors, we studied the effects of the K-ras gene on the tumorigenesis and development of the ovarian serous borderline tumor and malignancy on the basis of our previous investigations. Materials and Methods 51 formalin-fixed, paraffin-embedded tissue samples of ovarian serous tumors, including 18 conventional serous borderline tumors, 11 noninvasive micropapillary serous carcinomas, 12 invasive micropapillary serous carcinomas, 10 conventional serous carcinomas, and each of adjacent nomal tissue as control were studied for the observation of the mutation of...