Cloning, Expressing Of Human Bad Gene And Its Function Of Inducing Apoptosis On Human Basal Cell Carcinima Cell Line A431

Basal cell carcinoma (BCC) has another name called the leather tumour at the basal cell. It is the most common malignant skin tumour of face department, more in the middle part. It often needs the operation to excise the pathological change area to treat, whitch causing great influence on the patient's appearance. This disease developes slowly, seldomly metastasize. The surgery excises was the method that mainly adopted,but the facial deformity left after treating will bring heavy psychological burden to the patients, influencing the existant quality seriously. In recent years, the incidence of the basis cell cancer rises gradually, causing the extensive concern of the academia. Cell apoptosis was closely related to the generation of the rumour because of the oncogene activation or anti-oncogene inactivation which could lead the cell cycle out of control. The cell insufficient apoptosis was the important mechanism that lead to a lot of tumours. In recent years, with the further study to the mechanism of cell apoptosis , more and more researchers attempted to cure the cancer by leading the tumour cell to apoptos and had made the preliminary effect. Gene therapy means a method of transfering a certain hereditary material to the patients' cells and making it produce a marked effect in patients' bodies,in order to...