Protective Effects Of Atypical Antipsychotic On PC12 Cells And Their Mechanisms In Vivo

Schizophrenia is a severe illness that affects approximately 1% of the world's population. Atypical antipsychotic drugs risperidone, olanzapine, and quetiapine are widely used in the treatment of schizophrenia. These drugs block both dopamine and serotonin receptors, improving both positive and negative symptoms of schizophrenia, and have a lower propensity than typical antipsychotics to induce motor side effects. A key feature is that early and prolonged intervention with these drugs will improve long-term outcome; however the mechanisms of their action remain unknown. Based on these data, we present the hypothesis that atypical antipsychotic drugs may play a neuroprotective role during the treatment of schizophrenia. The present study examined the protective effects of the atypical antipsychotic drugs risperidone, olanzapine, and quetiapine on PC12 cells after serem withdrawal and those of the atypical antipsychotic drugs on injury of PC12 cells induced by rotenone . Experiment 1Objective To investigate the protective effect of atypical antipsychotic drugs risperidone, olanzapine, and quetiapine on neuronal cells. Methods PC12 cells differentiation were performed by adding NGF at the concentration of 100 mg/L for 7 days in vitro, then these cells were randomly divided into six groups: serum-cultured, serum-free, haloperidol , risperidone, olanzapine,...