The Survival Of Olfactory Ensheathing Cells In Freeze-thawed Peripheral Nerve Grafts And Its Effect On Axonal Regeneration Of Adult Rat Optic Nerve

Damage to the central nervous system (CNS) is always followed by an irreversible axon degeneration of injured neurons. Since the axonal regeneration is very difficult, many kinds of attempts have been made to enhance neuronal survival and axonal regeneration of axotomized neurons. Optic nerve and retina are derivatives of CNS, optic nerve is composed of axonal of retinal ganglion cells (RGCs). Many regeneration studies have been carried out using the retina and optic nerve as a model system, because the somata and myelinated axons can be manipulated separately and the retina can be studied as a flat-mounted preparation which facilitates the analysis of the RGCs in the entire retina.Peripheral nerve grafts have been thinking a very effectually means to enhance the axonal regeneration of damaged RGCs. But...