Expression Of β-amyloid And Presenilin-1 After Reperfusion Of Transiently Incomplete Brain Ischemia In Rat

Background and ObjectiveAlzheimer's disease(AD) is the commonest cause of dementia in the elderly.The pathogenesis and treatment study of AD has been the focus of nerve system degradation disease research.Some genes mutations have been indentified as risk factors of AD. So far, in familial AD cases,three AD causative genes were identified: the APP gene on chromosome 21 and the presenilin 1 (PS1) and 2 (PS2) genes on chromosome 14 and 1, respectively. The familial AD cases are less frequent than sporadic AD cases. To date, the cause of sporadic AD have not been fully elucidated.Researchers have made effort to look for new risk factors for AD.Recent epidemiological and clinical-pathological data suggest that some overlaps between Alzheimer's disease and cerebrovascular lesions. Epidemiological studies have shown that vascular risk factors may be involved in AD. Vascular lesions have been showed in most AD patients. The overlaps have drawn much attention on the mechanisms of vascular factors's role in AD.