Effect Of ROS And BMK1 On The Gastric Mucosal Cell Proliferation In The Chronic Alcohol Drinking Rats

Chronic ethanol feeding has been implicated in the gastric mucosal cell proliferation. However, the mechanism of this proliferation remains poorly understood. We developed a chronic drinking rat model to investigate the correlation between the gastric mucosal cell proliferation and the low concentration alcohol intake and the molecular events involved in the long-term effect of ethanol feeding on cell proliferation, focusing especially on its effects on the reactive oxygen species (ROS) and extracellular signal-regulated kinases (ERKs), big mitogen-activated protein kinases-1(BMK1), c-Jun N-terminal kinase(JNK) signaling pathway in rat stomach. Adult male Sprague-Dawley (SD) rats were randomly divided into 4 groups: control group, administered with tap water; ethanol group, administered with 6% ethanol in the drinking water; quercetin group, administered with quercetin (100mg/kg) by intragastric gavage twice a day; ethanol+quercetin...