The Potential Mechanisms Of JWA Gene In K562 Cells Responsive To The Stimulations Induced By Hemin And Thermal Stress

Human diseases are usually the consequences of the interactions between environmental agents and genetic. The present study is focus on the behind mechanisms of JWA gene in responding the stimulations of both hemin and thermal stress in K562 cells.In 1998, Zhou et al cloned a novel environment-responsive gene from human bronchial epithelial (HBE) cells by using the differential display high-throughput technique (AF070523). The new gene, named JWA, is broadly distributed in most of examined eukaryotic cells and tissues. The intracellular distribution of JWA protein encoded by the gene is very similar to that of cytoskeleton under immunofluorescence microscopy. The gene expressions are modulated by some cell differentiation inducers, like hemin. Our recent studies showed that JWA is also a functional protein associated with cell differentiation and apoptosis, and might play an important role in development...