Changes Of Serium Concentration Of Pregnancy-associated Protein-A And Its Relationship With Unstable Coronary Plaque In Patients With Acute Coronary Syndrome

Objective: Acute coronary syndrome (ACS) is a group of serious cardiovascular diseases,including unstable angina(UA),non-ST segment elevation myocardial infartion(NSTEMI) and ST-segment elevation myocardial infartion(STEMI). Rupture of atherosclerotic plaques, and resultant platelet aggregation and thrombus formation is believed to be responsible for most of the development of ACS. In the process,unstable plaque rupture is the most important initiating factor. To identified the instable plaque is critical for preventing and curing ACS . Recently,it has been demonstrated that circulation levels of pregnancy associated plasma protein-A(PAPP-A) are elevated in ACS patients. The elevated circulating PAPP-A level is related to instability of plaque, and it may have predictive value for prognosis of ACS. The purpose of this study is to investigate the changes of circulating PAPP-A level and the relationship between PAPP-A concentration and the instability of coronary atherosclerotic plaque in patients with ACS.Material and Method:.Totall 88 patients who were suspected suffering from coronary heart disease(CHD) and received coronary angiogram were selected for the study. 26 patients with normal coronary angiography(CAG) and free of CHD as controls; 62 patients had angiographic stenosis of coronary arteries, including 22 patients with stable angina, 20 patients with unstable angina and 20 patients with acute myocardial infarction.Serum PAPP-A level was determined by ELISA. CRP and CKMB level was determined by immunoturbidimetry and monitoring respectively. All coronary...