Factors Affecting Aortic Augmentation Index In Continuous Ambulatory Peritoneal Dialysis Patients

Objective: Dialysis is an established method for end-stage renaldisease (ESRD) patients. However, a series of comorbidity would develop along with time on dialysis, and cardiovascular disease was the leading cause of death in this population. The worsening of aortic function was a marker of increased cardiovascular risk, which predicted cardiovascular events. In the present study, we investigated the relationship between aortic stiffness and its influencing factors, and monitored the change of aortic stiffness, trying to provide some evidence for clinic precaution and treatment of cardiovascular complication.Methods: From March 1, 2005 to July 1, 2005, 163 patients who hadbeen on CAPD more than three months in the First Hospital of Peking University were enrolled. Ninety-two healthy volunteers, who were normotensive and had no renal disease, diabetes or coronary artery disease (CAD), severed as normal controls. BP, height, body weight were measured for three times and obtained a mean value. Augmentation Index (AIx) were measured by Sphygmocor (Sydney Australia).Results: Compared to normal controls, central aortic pressure andAIx increased significantly in CAPD patients (P<0. 05). In CAPD patients, female patients had higher AIx than male patients. AIx in > 65 years old group were significantly higher than <65 years old group (P<0.05).