| lschemic cerebrovascular disease (ICVD) is usually a consequence of atherosclerosis and is the commonest cause of stroke. With high morbidity, high disability rate, high recurrence rate and low mortality, cerebrovascular disease has been one of the most devastating epidemics of our time. As we know, thrombolytic therapy and protective therapy of drug are still the major measurement in the treatment of ischemic brain vascular diseases at present, and the protective effects of Chinese traditional medicines are being paid more and more attention to. Recent study has revealed that N-methyl-D-aspartate (NMDA) receptors, a subclass of excitatory amino acid receptors, may play an important role in ICVD. Nowadays, theory of acute cerebral accident is transitional from the cognition of "blood suspension→no substrate→energy failure→cell death" to the theory of neurotoxicity cascade reaction, at least including four different but interconnected mechanisms: exitotoxicity, infarction surrounding depolarization, inflammation and programmed cell death. Cascade reaction is initiated from exitotoxicity; that is, exitotoxicity is the most important process in the accidence of acute cerebral injury. Recently excitotoxicity has been described in virtually every region of the CNS and is thought to stimulate a series of linked events that lead to cell death of ischemic cerebrovascular vascular disease. The NMDA receptor is a heteromenc structure consisting of four or five subunits. Assembly of a functional receptor requires the presence of an NRl subunit, which is derived from a single gene and exists in at least eight different splice variant forms, along with one or more NR2 subunits (NR2A, NR2B, NR2C and NR2D) and/or a NR3 subunit, all derived from separate genes. Recombination studies have shown that the combination of an NRl subunit with a NR2 or NR3 subunit results in a functional...
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