Synthesis And Evaluation Of Ferulaic Acid And Its Analogs As Antioxidants

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid, also named as Ferulic acid (FA), which widely distributed in plants. FA is one of the strongest bioactive compounds in angelica, equisetum, and other Chinese herbal medicine. Because of its strong antioxidant activity, FA was widely used in medicine, cosmetic and health food. Recently, FA's biological activity has been extensively studied, and found many its related compounds also have the antioxidant activity. At present, the structure modifications to FA are mainly focused on the carboxyl group. FA's ester, acyl and salt form were reported. But the modification to FA's aromatic ring was seldom reported, so we synthesize a series of hydroxycinnamic acid derivatives. The antioxidant activities in vitro were evaluated by the level of scavenging DPPH radicals and hydroxyl radicals. Using the myocardial cell hypoxia/reoxygenation (H/R) model investigate the effect of defending the injury induced by H/R.1 Synthesize Ferulic Acid and Its AnalogsSynthesize the related substituted 4-hydroxybenzaldehyde, and different substituted 4-hydroxybenzaldehyde was reacted with maloic acid to synthesize Ferulic acid and its analogs. Their chemical structures were determined by IR, ~1HNMR, MS and elemental analysis.Result: Target compounds were white or yellow crystal, melting point were about 200～230℃. Data of Elemental Analysis and Spectroscopy were coincident with character of chemical structure.2 Scavenging DPPH · activity of Ferulic Acid and Its AnalogsTarget compounds were prepared to five different level DMSO solution, and...