Transmission Disequilibrium Analysis Of Polymorphism Rs3924999 On NRG1 Gene With Schizophrenia

Background and Objective: Schizophrenia is a group of clinical syndromes with unknown causation. A number of studies indicate genetic factors are the most important in the pathogenesis of schizophrenia. Several hypotheses have been advanced to explain the etiology of schizophrenia. Two major neurochemical theories, the dopaminergic hypothesis and the glutamatergic hypothesis, are the most prominent. The limitations in symptom treatment by neuroleptics , yet the dopaminergic and glutamatergic hypothesis do not fully explain the pathophysiology of schizophrenia. Therefore, it has been suggested that schizophrena may be a neurodevelopmental disorder , still involving genetic factors and defects in the neurotransmitter systems Two major neurochemical theories, the dopaminergic hypothesis and the glutamatergic hypothesis, are the most prominent. The limitations in symptom treatment by neuroleptics and furthermore the dopaminergic and glutamatergic hypothesis do not fully explain the pathophysiology of schizophrenia. Therefore, it has been suggested that schizophrena may be a neurodevelopmental disorder , still involving genetic factors and defects in the neurotransmitter systems. In the study of candidate gene, neuregulin 1 gene is fascinating. NRG1 gene encoding NRG1 and located on the chromosome 8p22-12 region. NRG1 plays a role as a multifunctional factor in the...