A Study Of The Tei Index In Evaluation Of Left Ventricular Function And The Effects Of Inhalation Of Prostaglandin E₁ To Pulmonary Hypertension In Children With Left To Right Shunting Congenital Heart Disease

Background: Left to right shunting congenital heart disease (CHD) is common seen in children, which can display dysfunction of left ventricle (LV) in early period and lead to pulmonary hypertension (PH) if treatment is delayed.Objective: This study was designed to assess the characteristics of LV function detecting by echocardiography and assess the effects of inhalation of prostaglandin E₁ (PGE₁) in children with PH secondary to left to right shunting CHD. Methods: Ninety children with CHD and fifty-five age-matched healthy children were studied respectively using mitral valve flow spectrum (MVF) ejection fraction (EF) and total ejection isovolume index (Tei index). The patients were divided into CHD without PH group (CHD group) and CHD with PH group (PH group) according to their pulmonary pressure. From Doppler tracings of mitral inflow, peak early diastolic (E) peak late diastolic filling velocities (A) and the ratio of E/A were measured. Tei index was obtained by measuring the ratio of isovolumic time [isovolumic contraction time(ICT) and isovolumic relaxation time (IRT)] to the...