Experimental Study On Octreotide Therapy For Neovascularization Of The Rat Cornea

Objective: Avascularity is the key feature of cornea. Corneal neovascularization would develop because of infection, surgical trauma,et al. Acuity of vision would be seriously damaged.The mechanism of neovascularization is multiplicity. Wilderness growth factors and regulatory factors participate this process, and keep balance between enhancement and containment. The purpose of this study was to detected the expression of VEGF,PEDF and MMP-2,TIMP-2 in the rat alkali-burned cornea, and provide theoretical basis for effective treatment for cornea alkali burns.Ocular trauma is an ophthalmopathy frequently originating neovascularization, especially severe chemical injury, which accounted about 10% corneal infective dose. Therefore it is important to positively research a utility and small adverse reaction managemen method. This experiment is considering the effect of the octretide for alkali burn of the rat cornea, to investigate the effective and approach the mechanism of action.Methods: Midrange alkali burn of the rat cornea model was...