The Mechanisms Of Electroacupuncture On Activating Endogenous Angiogenesis In Brain Tissues Of Rats Subjected To Focal Cerebral Ischemia/Reperfusion

Background In recent years, a new concept was born in ischemic cerebrovascular disease,which was neurovascular unit. Neurovascular unit was an integral one that consisted of neuron,vascular endothelial cells,et al. This concept focused on interaction between cell to cell and cell to matrix. We used to emphasize on neuron,but not vascular endothelial cells. Reperfusion in ischemic area as soon as possible and rescuing dying neuron,vascular endothelial cells after cerebral ischemia was main point in the therapy of ischemic cerebrovascular disease. Based on vascular endothelial cells,incenting angiogenesis in brain tissuses is likely to be a new clinic method.Angiogenesis after cerebral ischemia was regulated by a series of vascular factors.Angiogenic growth factors played a role in positive regulation,such as endothelial specific facters VEGF and Ang. They interacted each other and together regulated every aspect of angiogenesis. VEGF/VEGFR system likely played a critical role in the early stage of...