The Effects Of IL-1β, AA On Differentiation Into Dopaminergic Neurons From NSC In Vitro

Background and objectivesNeural stem cell is one of the most important investigation in neurobiology of science. NSC brings a new hope for injury and degeneration of CNS with its self-renewing and multiple-differentiation. Parkinson disease is a neurodegenerative disease of dopaminergic neurons .We can develop a further investigation and found on the self-renewing and multiple-differentiation of NSC. Objective is to explore the effects of IL-1β, AA, IL-1βand AA on differentiation into dopaminergic neurons from neural stem cells in vitro.MethodsIsolate and culture mesencephalic neural stem cells from SD rats of 1 day age in vitro . we use immunocytochemical techniques to detect TH-positive neurons induced by interleukin-1 bate,AA,interleukin-1 bate and AA.ResultsNestin was detected in cells of clone and 41folds was added during the 10...