| Background Acute respiratory distress syndrom is a clinlical emergency characterized by persistant hypoximia, with a high mobidity and mortality. Acute lung injury is the fundermental pathological changes of ARDS. It causes increased vascular permeability and edema. The pathogenesis of the disorder is very complicated and still riddled. In clinic, there is no effective treatment method. ALI is caused by excessive inflammatory reaction, numerous effective cells (such as macrophage, neutrophil, et, al.) and inflammatory media take part in this reaction.So it is necessary to find a way, which dose not affect self-protection, to inhibit inflammatory damage. Ecdysterone is a steride molecule ubiquitous in nature and functions as an anti-inflammatory, anti-oxdant, anti-apoptosis agent with little toxicity in vivo and in vitro.It had been reported to have protective effect of lung contusion from impact. Whether it has protective effect on lipopolysaccharide- induced ALI and its probable mechanisms have not yet reported.The research is divided to 2 parts:1.Changes of mouse pulmonary vascular permeability after acute lung injury in...
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