Neuroprotective Effects Of RFP On MPTP-induced DA Neurons Apoptosis In C57BL Mice

BackgroundParkinson's disease(PD), also named "paralysis agitans", is a degeneration disease of the central neural system with high morbidity in the elders. The selective degeneration, death and depletion of the dopamine (DA) energetic neurons in the compact part of substantia nigra of midbrain accounts the most for the pathology of PD. The disorder of the function of basal nuclei with deficient DA in corpora striata caused by the remnant DA neurons' decreasing capability of DA generation also contributes to the disease. PD has four essential characteristics, such as static tremor, rigidity, bradykinesia and postural unsteadiness. The foreign statistic data indicates that the morbidity of PD is 0.1% to 0.2%, and amounts to 1.4% in the people over 55 years old. The patients of PD become more and more with the aging of the society.The aetiology of PD has not been identified yet by now. It is considered that the death (mainly apoptosis) of DA energetic neurons in substantia nigra of midbrain caused by heredity, aging, environment, oxidative stress, immune abnormality, excitory amino acids toxicity and dysfunction of mitochondria may be answer. So, the comprehensive route to treat PD is the protection of neuron and the fight against cell apoptosis. Now, there are 5 therapeutic methods coming into being, including...