Effects Of Different Exercise Intensity On The Expression Of Hypoxia Inducible Factor-1α MRNA In Skeletal Muscle Of Rats

Background:Oxygen is one of the most important matters in the life of human being. There are three normal hypoxia conditions which involves physiological hypoxia, pathological hypoxia and athletics hypoxia. Appropriate exercise can improve the consumption of oxygen, which cut down the differential pressure of oxygen when the consumption is beyond the provision of oxygen. The differential pressure of oxygen in the skeletal muscle cell may drop into 3-4 Torr and it can produce persistent stimulus which might be some positive changes to adjust to the exercise. However, constant high-intensity exercise may damage to skeletal muscle and induce to apoptosis or necrosis, where hypoxia inducible factor-1 plays an important role. Hypoxia inducible factor-1 was discovered in the Hep3B cell of hepatocyte cancer, which can express all kinds of cells in the mammal. Hypoxia inducible factor-1 was consistent of a subunit and 8 subunit. The research of hypoxia inducible factor-1a has been the focus on the territories of tumor, brain and spinal cord, but the reports on the territories of skeletal muscle are few at present. Our experiment team has confirmed that hypoxia combined with training is important to the promotion of accustomization to hypoxia. We will go on investigating changes of hypoxia inducible factor-1a which...