Variance Of Spectrum Of Matrix Metalloproteinases In The Embryo Implantation Process

Successful human placentation requires that extravillous cytotrophoblasts (EVCT) rapidly "invade genetically dissimilar maternal tissues during the early stages of pregnancy. EVCT differentiate from cytotrophoblasts (CTB). Although EVCT behave like metastatic cells, in vivo they are only transiently invasive (first trimester) and their invasion is normally limited only to the endometrium and to the proximal third of the myometrium. The trophoblast invasion is precisely controlled, and errors can have extremely adverse consequences. For example, shallow invasion is associated with preeclampsia and about half the pregnancies that are complicated by intrauterine growth retardation. Overly aggressive invasion, through the deeper portions of the myometrium and beyond, is associated with placental site tumors, choriocarcinoma, and placenta accreta. To research MMPs which effect the temperate invasion of trophoblasts, it will provide to the theoretical foundation for the prevention and cure of deseases caused by trophoblasts invasion abnormality, to maintain a successful pregnancy.Migration and invasion of trophoblasts into the uterine wall and maternal vasculature are pivotal to the success of placentation. Interstitial trophoblasts invade the uterine tissue, anchoring the placenta to the uterus, and preparing the decidual spiral arteries for endovascular migration. Extravillous trophoblasts migrate to the maternal spiral arteries, traverse the endothelium, and then migrate along its luminal...