Preliminary Studies Of Prevalence About Brugada-type Electrocardiogram In Healthy Examination And Mutation Screening Of SCN5A Gene

Background Brugada syndrome is associated with high risk for sudden death in all age, especially in male youth. An essential condition for its diagnosis is Brugada-type electrocardiogram (ECG), which character is a typical ECG pattern that consists of varying degrees of right bundle branch block (RBBB) and ST-segment elevation in the V1-V3 leads, coved or saddleback-shaped. According to the first consensus conference in the European Heart Rhythm Association, three ECG repolarization patterns in the right precordial leads are recognized. Type 1 is diagnostic of Brugada syndrome and is characterized by a coved ST-segment elevation ≥2mm followed by a negative T wave. Type 2 has a saddleback appearance with a high take-off ST-segment elevation of ≥2mm followed by a trough displaying ≥1mm ST elevation followed by either a positive or a biphasic T-wave. Type 3 has either a saddleback or acoved appearance with an ST-segment elevation of <1mm. There are many overseas reports about the prevalence rate of Brugada-type ECG: in a Japanese study, Brugada-type ECG was observed in 70/10 000, typel appeared in 12/10 000; in US data, 18 piece Brugada ECGs was find in 55446 ECGs, but no type 1 in which. In China, data in this aspect is yet to be established.Inheritance of the Brugada syndrome is via an autosomal dominant mode of transmission. The only gene known to be linked to Brugada syndrome is SCN5A,...