Experimental Study On Cerebral Protection Of L-arginine During Deep Hypothermic Circulatory Arrest

Techniques of deep hypothermic circulatory arrest (DHCA) can provide a bloodless and quite operating area, and DHCA having been widely used for surgical treatment on complex congenital cardiovascular disease or complex great vessel disease. In recent years, with the improvement of neuroprotection, and more cooperation between divisions made DHCA used more widely. DHCA had been used for treatment on many diseases such as congenital cardiovascular disease, dissection of aorta, aortic arch aneurysm, intracranial giant aneurysm, Bucld-Chiari syndrome, trauma of main vessel and tumors involving main vessel. However, central nervous system dysfunction continues to represent significant morbidity and associated mortality in patients undergoing operation on great vessels. Although surgical techniques, anesthetic management, and postoperative care have significantly improved, DHCA-induced cerebral injury remains problematic, and there are few efficacious means for prevention or treatment. The mechanism of this injury is complex and is not very clear. Nitric oxide (NO) is a gas signaling molecule mattered with simple structure instability, and may play an important and controversial role in ischemic-reperfusion brain injury according to present study. With the advance of study about isoforms of NOS, there is increasing evidence that endothelial nitric oxides synthase mediates protective effects to early...