A New Orthotopic Model Of Human Bladder Cancer Expressing Green Fluorescent Protein

Background Bladder cancer is the most prevalent urinary tumor characterized by infiltration,relapse and malignant changes.It's incidence rate ranks 4th in male patients and 8th in female patients who with tumors. Electrocision is always the first choice for most patients with bladder cancer,but the recurrence rate can reach up to about 50-70% after being treated with electrocisionm within 1year.Because of the high incidence rate and recurrence rate,many research workers study on bladde cancer trying to find a perfect treatment prescription.Animal experiments must be carried out before some new methods being spreaded in clinical experimetns,so it is extremely important to eatablish a satisfactory animal model.Human cancer cells were firstly transplanted into the body of nude mouse successfully in 1969 by Ryaard,since then,animal models of most of the human tumors were established with nude mice,and subcutaneous inoculation was the most popular and convenient method to establish an animal tumor model.Surely,the new tumor can , to some degrees,imitate the characteristics of the morphology , biology and biochemistry of original tumors and can be easily observed.But for most human tumors, these tumors were dystopic animal models which had some different biological behaviour from that of original human tumors. For this reason,some...