Differenation Of Recipient Bone Marrow Derived Stem Cells Into Vascular Endothelial Cells In Rat Liver Allograft

Background: In 1963, Starzl performed the first orthotopic liver transplantation. Over the past 40 years, advances in immunosuppression, organ preservation, surgical techniques and perioperative management have resulted in a great improvement in liver transplantation survival. Liver transplantation has now been widely accepted as an effective therapeutic modality for a variety of irreversible acute and chronic liver diseases for which no satisfactory therapy is available. But transplantation rejection is one of the most important reasons for allograft loss at the same time. The essence of transplantation rejection is a patho-physiological process during which allograft is destructed both in structure and function by the recipient' specific immune reaction against its intrusion. So theoretically, if the transplanted liver could be substituted by recipient derived cells, it would not be rejected.Bone marrow stem cells contain hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs) and multipotent adult progenitor cells (MAPCs). Recent findings indicate that adult bone marrow stem cells from both rodent and human being have the ability to differentiate into nerve cells, cardiac muscle cells,hepatic cells, epithelial cells, et al. Recipient bone marrow derived stem cells can avoid immune rejection. So if recipient bone marrow derived stem cells could...