The Successive Administration Of Taurine And Strythnine Improves The Brain Self-repair After Global Ischemia

The ischemic diseases of brain, the main cause of disability and mortality, threat the human's health severely. However we have no adequate confirmed therapeutical methods for these diseases. The recent studies of adult neurogenesis are beginning to shed new light on the therapy of ischemic brain injury. Neural stem cells, existing in the adult mammal brain throughout life, can renew and give rise to new neurons, astrocytes, and oligodendrocytes, adapting to the physiological demands and pathological insults. Accumulating evidence suggests that ischemic brain injuries, transient focal or global, potently stimulate neurogenesis in proliferative regions of adult brains. Neonatal neurons can migrate into the areas of the infarction, substituting some dead neurons. Brains can partly repair themselves by triggering neurogenesis in the central nervous system after the brain ischemia that typifies a stroke. If we augment neurogenesis by pharmacological interference, the brain self-repair can be improved, which could be a new approach for the therapy of ischemic brain injury.Taurine, one kind of neuronal protective agents, can decrease cell apoptosis induced by ischemia if treated before ischemia, but not after ischemia. Our past...