Study On The Insulin Sensitivity And Glycemic Excursions In The Late Second Or Early Third Trimester Of Pregnancy

BACKGROUNDGestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. It does exclude diabetes mellitus and impaired glucose tolerance but not exclude diagnosed mellitus before pregnancy. The prevalence of GDM may range from 1 to 14% of all pregnancies, about 90% of all diabetes mellitus pregnancy. It not only makes short-term harm but also makes long-term harm to fetus and pregnant women. Short-term harm means increasing the risk of hydramnios, premature delivery, death fetus, abortion in pregnant women, and increasing the risk of maternal hypertensive disorders, ketoacidosis, serious retinal alter, dystocia, and the need for cesarean delivery. The risk for fetus main represent in macrosomia, neonatal respiratory distress syndrome, neonatal hypoglycemia, neonatal hyperbilirubinemia, and neonatal death etc. Long-term harm in women with GDM means it will increasethe risk of the development of diabetes, usually type 2, after pregnancy. Offspring of women with GDM are at increasing risk of obesity, glucose intolerance, and diabetes in late adolescence and young adulthood. How to make early detection and early intervention becomes one of the most important issues in order to increase the risk of...