The Study Of Correlation Between Cardiotrophin-1 Gene And Dilated Cardiomyopathy

Background Dilated cardiomyopathy(DCM), which is characterized by left ventricular or biventricular dilatation and reduced systolic function, is the most major cause of congestive heart failure and heart transplantation. The pathogenetic reasons of DCM are numerous and complicated, 20%-30% of which are associated with genetic aspects. Some researches have indicated that many gene mutations may be related to DCM.Cardiotrophin-1 (CT-1) is amember of the interleukin-6 family group, which can induce cardiac myocyte hypertrophy.