In Vitro Investigate The Regulation Of The Lactobacillus On The Growth Of Helicobacter Pylori SS1 And Helicobacter Pylori-induced Acute Inflammatory Reaction To SGC7901 Cells

Background:Helicobacter pylori leads to pathopoiesis not only through it's adhesion effect and virulence factor could direct injury mucous cell by also through organism aim to cell generated inmmunize reaction damage tissue. It correlates with nosogenesis of chronic gastritis ,peptic ulcer,gastric cancer and MALT. It is well known that H.pylori leads to inflammatory reaction as follow:firstly, H.pylori adhesion on the gastric mucous epithelial cell,then the cell framework reorganized and tyrosine phosphorylation were occurrenced in gastric epithelial cell, at last NF-κB and MAPK were activatied to produce proinflammatory factor such as IL-8.For the past few years many reseach had indicated lactobacillus dominical probiotic bacteria were microorganisms that had a favorable influence on gastric epithelial cell inflammation in part by their effect on the gastric tract microflora . Lactobacillus could inhibit or kill H.pylori through inhibited H.pylori field planting and secreted lactic acid and antibacterial peptide, moreover they could lessen H.pylori pathogenicity and inflammation degree through regulated organism immune...