Investigate The Change Of The First-phase Insulin Secretion In The First-degree Relatives With Normal Glucose Tolerance Of Chinese Type 2 Diabetes Mellitus

Objective With the improvement of society, the acceleration of human living rhythm, sitting living style, high calorie intaking and genetic factor affecting, the prevalence of diabetes rising year by year. Diabetes mellitus always is a cosmopolitism tough problem, as yet still no statifactory treatment method can cure diabetes, clinically chief control blood glucose, depressurizate, lower blood fat, improve micro-circulation,but can not control diabetic progress.Type 2 diabetes mellitus (T2DM) is major in china, about account 90～95%.How To prevent and cure T2DM is a challenge to present medical staff, solve this tough problem must begin with pathogenesy of T2DM. So far, It is accepted that insulin secretion function defection and insulin resistance is the feature of T2DM. Many study confirmed the first phase insulin secretion of patients with impaired glucose tolerance have declined and T2DM have disappeared. It can be seen that the first phase insulin secretion play an important role in the development of diabetes.The first phase insulin secretion can increase liver glucose Uptake and decrease liver glucose output, inhibit glicentin Secretion...