| Objective:To explore the effects and complications of allogeneic peripheral blood stem cell transplantation for chronic myeloid leukemia(CML).Methods:We retrospectively analyzed 24 CML patients who were treated with HLA matched or one loci mismatched allogeneic blood stem cell transplantation from 2002 to 2005.Among them,17 patients were male,7 patients were female,and the median age was 41(range 32-58).18 patients were at chronic phase,and another 6 patients were at accelerated phase.5 patients accepted myeloablative conditioning regimen and stem cells were from siblings.13 patients accepted nonmyeloablative conditioning regimen and stem cells were from siblings.1 patient accepted myeloablative conditioning regimen and stem cells were from unrelated donors.5 patients accepted nonmyeloablative conditioning regimen and stem cells were from unrelated donors.The myeloablative conditioning regimen consisted of busulfan and cyclophosphamide.The nonmyeloablative conditioning regimen consisted of fludarabine and busulfan. Cyclosporine A (CsA) and mycophenolate mofetil (MMF) were used to prophylaxis graft versus host disease(GVHD), prostaglandin E1 was used to prophylaxis veno-occlusive disease (VOD) and mesna was used to prophylaxis hemorrhagic cystitis (HC).Results:We analyzed the conditions of the patients before transplantation, disease stage was different between the myeloablative conditioning group and nonmyeloablative conditioning group(P=0.018),but there was no significant difference about donor type.All 24 patients were engrafted successfully.The median time for ANC>0.5×109/L was 12 days and for Plt>20×109/L was 13 days.The rate of VOD,aGVHD,cGVHD,HC and IP was 8.3%(2 patients),62.2%(15 patients),12.5%(3 patients),12.5%(3 patients) and 20.8%(5 patients),respectively.Among the patients who accepted myeloablative conditioning regimen,the rate of VOD,aGVHD,cGVHD,HC and IP was 11.1%,66.7%,16.7%,16.7% and 0%,respectively.Among the patients who accepted nonmyeloablative conditioning... |
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