The Study Of Correlations Between Lipid Peroxidation And Gestational Diabetes Mellitus, Fetal Growth Restriction And Premature Rupture Of Membrane At Term

ObjectivesTo investigate the effects of lipid peroxidation (LPO) on pathogenesis of gestational diabetes mellitus (GDM), fetal growth restriction (FGR) and premature rupture of membrane at term (tPROM) and the correlations between LPO and these diseases by analyzing LPO in normal pregnancy, GDM, FGR and tPROM in different gestational stages.MethodsAll pregnant women recruited in this study were regularly performed perinatal care in the department of O&G in the 1st Affiliated Hospital of Jinan University. 31 pregnant women diagnosed as GDM by oral glucose tolerance tests (OGTT) were recruited and served as GDM group. The pregnant women in GDM group were managed by dietary control only and their capillary whole blood glucose being kept at appropriate level. 38 pregnant women with normal blood glucose level, diagnosed as FGR after 32 gestational weeks, were recruited and served as FGR group. The S/D value of the umbilical artery blood flow of the pregnant women in FGR group who delivered at term, was normal after a series of medical management. 32 pregnant women whose fetal membranes ruptured before onset of labor were recruited and served as tPROM group. The pregnant women in tPROM group delivered appropriated size babies at term without any sign of inflammation. Urine samples from all cases in different groups were collected in three gestational stages respectively: second trimester (from 16 to 23⁺⁶gestational weeks ), late pregnancy (from 28 to 36⁺⁶gestational weeks) and term pregnancy (from 37 to 40 gestational...