Construction Of Cell Model Stably Co-Expressing Amyloid Precursor Protein And α7 Nicotinic Acetylcholine Receptor

Alzheimer's disease (AD) is a kind of neurodegeneration disease, which is common among the old people and is characterized by progressing dementia. The accumulation of beta-amyloid protein (Aβ) is thought to be the hallmark and contribute most to the generation of AD which can be sporadic or familial. Most of AD cases are sporadic which result from heterogeneous causes, including genetic and environmental factors. Many studies in AD research focus on the effect of genetic factors on AD pathogenesis, revealing that mutation can affect the activity ofγ-secretase by which the amyloid precursor protein (APP) can be processed into Aβ. However, it is not well known whether and how the environmental and physiological signals can regulate theγ-secretase activity and Aβproduction. Epidemiological studies have shown that the rate of AD is relatively low among the smoking people,...