Circuit Design Of Central Neural Signal Recording And Application Research

A lot of patients in the world are suffering from nerve damage or central neural system (CNS) diseases. How to restore the injured neural system and make the patients have a normal life is challenging for us. With the development of the microelectronics and neurobiology and associated fields, the microelectronic technique could be utilized to build an in-body embedded micro module which can record the neural signals from one neuron stump, to make signal processing, and regenerate the signals in the another neuron stump, through which nerve prosthesis can be realized and has become to a popular research field.The whole central neural function regeneration system includes five modules:A microelectrode contacted or covered onto the neural stump near the damage point, an amplifier in which the signal will be amplified up to some suitable amplitude, a signal processor following the amplifier,a function electrical stimulation (FES) signal generator, which is similar to that one from a normal neural channel and the neural function is rebuilt in a single channel.The neural signal detection, which is the first and one of the most important stage of CNS, aims to pick-up useful information from the bioelectrical signal on the neural stump so that it can supply source signals for subsequent processing circuits and/or FES circuits.Circuits for processing the output signals from the 12 cuff electrodes and an electronic circuit for recording signals from the 10 shaft electrodes are proposed. The three-stage amplifiers are adopted in cuff electrode recording circuits and a 2nd-order band-pass filter is adopted in our circuit design. The two-stage amplifiers are adopted shaft electrode recording circuit with operational amplifiers and Instrumentation Amplifiers. They can amplify weak signals and thus be used for neural signal amplification and be proved by the experiments on SD (Sprague Dawley) rats containing spinal nerve, and it is as well as sciatic nerve.