The Relationships Between Insulin Resistance Index And Inflammatory Cytokines And Coronary Artery Diseases In Old-age Male

To observe the relationships between insulin resistance index(IRI) and inflammatory cytokines and coronary artery diseases in old male patients with coronary artery diseases (CAD).Methods80 males were enrolled our groups who taken coronary angiography in the First affiliated hospital of Zhejiang University from June to November in 2006 .they all suffered diabetes. niellitus : 50 coronary positive patients as case group vs 30 negative as control, and case group wasdivided into two subgroups, 30 with stenting vs 20 without stenting. Inflammatory cytokines(TNF-α , CRP, IL-6, IL-8, IL- 18), the 1evels of serum insulin and glucose (before breakfast) were analyzed respectively, the IRI was calculated by HOMA Model Formula.ResultsThe medium level of IRI in case group were significantly higher than that in control group ( P<0.05) , the level of IRI in stenting subgroup also show notable increase comparing with non-stenting subgroup(p<0.05).Inflammatory cytokines raised more remarkably in case group than control group (P<0.05), and stenting subgroup also increased more notably comparing with non-stenting subgroup (p<0.05).ConclusionsThe level of IRI increase markedly in old-age male with coronary disease, while inflammatory cytokines show observable increase in these patients.These suggest that high IRI level and inflammatory cytokines' elevation may have some relationship with the prevalence of coronary artery diseases.