Study Of Houttuyfonte Drugs

Houttuynia Cordata Injection is prepared by refined volatile ingrediants distilled from Houttuynia Cordata such as decanoylacetal dehyde, 2-methyheptenone and dodecanaldehyde etc. Modern pharmacology study provced that they had the founction of anti-bacteria, anti-virus and improving system immunity. Decanoylacetal dehyde is one of the most important active ingrediants for anti-bacterium, easy to aggregate and invalidation when in dissociative state. Sodium Houttuyfonate and Sodium New Houttuyfonate can be got from decanoylacetal dehyde by chmosynthesis, both of them can restrain G~+ or G~- germ effectively, either improve lick up ability of leukocyte and increase blood serum prophage concentration and have more stable chemical property.Nowdays in clinical Houttuynia Cordata Inejction and Sodium New Houttuyfonate Injection are uesd . Houttuynia Cordata Inejction brought a series adverse reactions due to different raw material, not perfect qulity controlling and technical distilling and complicated components etc. Although Sodium New Houttuyfonate is single in Sodium New Houttuyfonate Injection , it was limited during usage,which need advanced quality criterion and manufacturing technics. For example Tween-80 was uesd in Sodium New Houttuyfonate Injection and Houttuynia Cordata Inejction as a hydrotrophy agent, but Tween -80 can falldown blood pressure and bring slight hemolysis, and also it has a certain toxcity. Except this, Tween -80 can occur "qitan" , influence the solution's PH and available ingrediants.We mainly studied items as follows: the fingerprint analytical method of Houttuynia Cordata Materials and Houttuynia Cordata Injection, the synthetical craft of Sodium New Houttuyfonate, the structure corroboration of Sodium New...