A Clinical And Experimental Study Of ～(125)I Brachytherapy For Prostate Cancer

This research includes two parts:Part one: A clinical study of ¹²⁵I brachytherapy combined with total androgen blockade for prostate cancer.Objective: To investigat the clinical effects of ¹²⁵I implantation combined ewith total androgen blockade(TAB) in the treatment of adenocarcinama of the prostate. Methods: To analyze retrospectively 9 patients with stage C and stage D1 prostate cancer. All patients accepted the combined treatment of ¹²⁵I seeds intraoperative implantation, bitateral orchidectomy, and Flutaminde (250 mg every 8 hours) in this hospital. Results: Follow-up periods ranged from 12 to 36 months. After 6 months postoperatively, PSA value decreased from 72.1±20.4ng/ml preoperatively to 3.6±0.6 ng/ml (PSA decreased to <1 ng/mL in 6 patients), prostate volume dropped to 37.73±10.3cm3, and IPSS score dropped from 30.2±2.1 preoperatively to 11.5±5.3(P<0.05). After 12 months postoperatively, PSA decreased to 1.8±1.3ng/ml in 8 patients. In 1 patient with stage D prostate cancer PSA increased to 30.9 ng/ml. Conclusion: the procedure had the advantage of both radioactive seeds interstitial brachytherapy and total androgen blockade and was safe and effective with fewer complications. . It is believed that the combined use of ¹²⁵I implantation and total androgen blockade be one of the ideal treatment for prostate cancer.Part two: An experimental study radiation injury on rabbits urethra induced by interstitial ¹²⁵I seeds implantingObjective: to assess radiation injury on rabits urethra induced by interstitial ¹²⁵I seeds implanting. Methods: A total of 10 rabbits were randomly divided into experimental and control group with body weight 2.0～3.2kg. ¹²⁵I seeds was implanted near urethra under anaesthesia, and the irradiation doses by ¹²⁵I seeds were 0.4 mCi, 0.8 mCi and 1.2 mCi, respectively. then we detected the pathology of urethra and observed the morphologic change with H.E. at 4 weeks after seeds implanting, urethral X rays was performed in experimental group. Results: At the 4th week postoperative,. histopathological and ultrastructural changes of the urethral tissue were not obvious as compared to the contral group. Conclusion: In the rabbit model, there is an obvious dose response relationship for in the ¹²⁵I seeds. Intraoperative implantation of prescription dose ¹²⁵I seeds has no adverse effect on rabbit urethra;...