The Alberta Stroke Program CT Score And Outcome Of Patients With Acute Ischemic Stroke

Objective: To evaluate the role of the Alberta Stroke Program CT Score (ASPCTS) in prediction the functional outcome of patients with acute ischemic stroke.Methods: 70 patients with ischemic stroke were enrolled from the first affiliated hospital of Da Lian Medical University admiting from January to December in 2006. We performed ASPCTS and National Institutes of Health Stroke Scale (NIHSS) score when patients was most serious and used modified Rankin Scale (MRS) to assess 3-month functional outcome. Spearman's rank correlation coefficient was used to test the association between ASPCTS value and NIHSS score. Ordinal Logistic regression was used to examine the predictive ability of ASPECTS (0~2, 3~6 and 7~10) in terms of functional outcome (death, dependence and independence) in the presence of other potential risk factors that may modify the effect of ASPECTS (including age, sex, hypertension, diabetes mellitus, hyperlipemia and coronary artery disease).Results: There were 41 men and 29 women of all 70 patients. Men's average age was 65±13 and median ASPCTS was 8, when women was 68±13 and 8. The number of death, independence and dependence at the end of 3 month was 6, 10 and 26 separately in men and 9, 7 and 13 in women. The ASPCTS negtive correlated with the baseline NIHSS score (r=-0.927,p=0.000). Among ASPCTS and other potential risk factors (including age, sex, hypertension, diabetes mellitus, hyperlipemia and coronary artery disease), only ASPCTS, age and sex were correlated with 3-month functional outcome and the odds ratio was 0.263, 1.069 and 6.398 separately. If considering ASPCTS alone, value 0~2, 3~6 and 7~10indicated death, dependence and independence separately at the end of 3 month. The coincidence ratio of ASPCTS was 87% and NIHSS was 90%, but the pairχ2 test show there was no significant difference between these two ratio.Conclusions: ASPCTS is correlated with ischemic stroke severity, lower the value, more serious the patient. We can predict functional outcome of patients with acute ischemic stroke according to ASPCTS. Beside ASPCTS, patient's age and sex also impact the functional outcome.