MALT lymphomas distinct from those of lymph nodes are low-grade B-cell lymphomas. They are indolent neoplasms which tend to remain localized for a long time before spreading. MALT lymphoma cells may tend to move among MALTs probably via a selective homing system. Therefore, multiorgan MALT lymphomas are rather rare, especially those involving distant lymph nodes.We described here the case of a 71-year-old woman with a low-grade MALT lymphoma involving the stomach, duodenum, colon and left supraclavicular lymph nodes at the time of diagnosis. Meanwhile, we reviewed the literature and discovered that the therapy of multiorgan MALT lymphomas were quite different from that of local MALT lymphomas. Standard staging was necessary before the therapy. Patients with spread of high-grade gastric lymphoma to adjacent organs or tissues should be best treated with systemic chemotherapy.
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