Polymorphisms In COX-2 And PARP-1 And Susceptibility To Gastric Cancer

AIM: To investigate association between polymorphisms in COX-2 Val511Ala and PARP-1 Val762Ala and susceptibility to gastric cancer in Han Chinese population in Gansu district.Methods: A hospital-based, case-control study was performed involving 138 patients with gastric cancer and 110 controls without evidence of neoplasm and gastrointestinal diseases, using a PCR-RFLP method.Results: COX-2 511 Val/Ala or Ala/Ala genotype were overrepresented in the cases (38.4%) compared with controls (26.4%), (OR, 1.742; 95% CI, 1.009-3.005; P = 0.045); PARP-1 762 Ala/Ala genotype was overrepresented in the cases (11.5%) compared with controls (4.5%), (OR, 3.012; 95% CI, 1.054-8.603; P = 0.033) . Among H. pylori IgG positive subjects,COX-2 511 Val/Ala or Ala /Ala genotype carrier's risk for gastric cancer is 2.247 fold than Val/Val carrier's (OR, 2.247; 95%CI, 1.047-4.822; P = 0.045), PARP-1 762 Ala/Ala genotype carriers had 9.263 fold increased risk for developing gastric cancer compared with Val/Val carrier (OR, 9.263; 95% CI, 1.160-79.966; P = 0.014).The subjects carrying COX-2 Ala/Ala and PARP-1 Ala/Ala genotypes had 7.86 fold increased risk for gastric cancer compared with the subjects with COX-2 Val/Val and PARP-1 Val/Val genotypes (OR, 7.860; 95% CI, 0.938-65.839; P = 0.033).Conclusion: COX-2 511 Val/Ala or Ala /Ala genotype contribute to the increased susceptibility to gastric cancer. PARP-1 762Ala/Ala genotype is associated to elevated risk of gastric cancer. These results indicate that there are multiplicative joint effects between COX-2 511 Val/Ala and Hp infection, PARP-1 762 Val/Ala and Hp infection in the risk of developing gastric cancer. Gene-gene interaction of COX-2 511 Ala/Ala and PARP-1 762 Ala/Ala polymorphisms increased risk of gastric cancer in a supermultiplicative manner.