Pharmaceutical Studies On Naodesheng Oral Liquid

The formula of Naodesheng tablet(pill) comes from Chinese Pharmacopoeia, which is made of several Chinese herbs, including Radix Notoginseng, Rhizoma Ligustici Chuanxiong, Flos Carthami, Radix Puerariae and Fructus Crataegi. The major effects of this medicine include reducing stasis and improving blood circulation, mediating main and collateral channels, and regaining consciousness. It is a remedy for cerebral arteriosclerosis, stroke and sequelae of cerebral hemorrhage. The topic systematically reseach on extraction, purifying the effective component of Naodesheng, on the molding process, and on the appraisal of stability, which has achieved the topic design goal.In this research, orthogonal method was designed to screen the extraction procedure of all drug components to get the best one. Quantitative analysis was carried out on total notoginseng saponin, puerarin by spectrophotometer method, HPLC to ensure quality control of NDS oral liquid.When we studied the quality standard, we used the TLC to identify the Rhizona Ligustici Chuanxiong, Flos Carthami, radix puerariae respectively, the separation of the stains was apparent and the negative contrast was not disturbed. All of these proved that the method we used is specific. We used HPLC gradient elution method to determination the amount of Notoginsenoside R₁, Ginsenoside Rg₁ and Rb₁ in Naodesheng Oral Liquid. Their average recoveries: Notoginsenoside R₁ was 100.35% (RSD=1.69%) , Ginsenoside Rg₁ was99.95%(RSD=1.26%) and Ginsenoside Rb₁ was 100.32% (RSD=1.38%) , respectively. Through the tentative stability of Naodesheng, all of the results showed that the preparing technology is rational and the quality of this medicine is stable.In this research, under the guidance of the Chinese medicinal theory and practice, new technology was used as experimental method. The experiment will provide the drug efficacy and quality control evaluation standards for NDS new drug form, provide the scientific foundation for the big industry's production, set a good foundation for the research and exploration of new medicine.