The Relationship Of Plasma Homocysteine And Macrovascular Diseases In Type 2 Diabetics

Objective:As we know that macrovascular diseases such as coronary disease, cerebrovascular disease and peripheral vascular disease are one of the causes for the type 2 diabetes morbidity and mortality. Homocysteine(Hcy) is a kind of non-essential amino acid having sulfate group. It is the intermediary metabolite of acimetion. Recent studies have suggested that the elevated homocysteine is an independent risk factor for atherosclerosis (AS). But we know a little about it and other researcheres have different viewpoints about it in the type 2 diabetes mellitus with macrovascular diseases. The aims of the present study are to investigate the plasma homocysteine level and its relationship with macrovascular diseases in type 2 diabetes mellitus by detecting plasma Hcy, serum monocyte chemoattractant protein-1 (MCP-1) concentration and other clinical and biochemical datas.Methods:Sixty-two type 2 diabetes mellitus were divided into two groups, of which 31 were with macrovascular diseases (group DMMV) and 31 patients without macrovascular diseases (group DMN), and 28 normal people were in control group (group C). Both the plasma Hcy concentration and serum MCP-1 concentration were determined by ELISA assay. The clinical and biochemical datas were measured. All the statistical analysises were dealt with SPSS 10.0 software. Results:There were no obvious differences on ages and blood pressures between type 2 diabetes mellitus with and without macrovascular diseases(P>0.05). BMI levels of type 2 diabetes mellitus were higher than control group(P<0.05). The group of type 2 diabetes mellitus without macrovascular diseases had higher plasma Hcy,MCP-1,FPG,FINS,HOMA-IR,HbA1C,TC,TG,LDL level and had lower HDL level compared with the control group(P<0.05 respectively). The group of type 2 diabetes mellitus with macrovascular diseases had higher plasma Hcy,MCP-1,FPG,FINS,HOMA-IR,HbA1c,TC,TG,LDL level and had lower HDL level compared with the group of type 2 diabetes mellitus without macrovascular diseases(P<0.05 respectively). The plasma Hcy was positively correlated with plasma MCP-1,BMI,FINS,HOMA-IR (P<0.05 respectively) in the type 2 diabetes mellitus with macrovascular diseases group. All the statistical analysises were dealt with SPSS 10.0 software.Conclusion:1. The group of type 2 diabetes mellitus with macrovascular diseases had higher plasma Hcy level compared with the other two groups (P<0.05), which means Hcy is related with macrovascular diseases in type 2 diabetes mellitus.2. The group of type 2 diabetes mellitus with macrovascular diseases had higher plasma Hcy,FINS,HOMA-IR level compared with the other two groups (P<0.05). The plasma Hcy level was positively correlated with BMI,FINS,HOMA-IR (P<0.05 respectively) in the type 2 diabetes mellitus with macrovascular diseases group, which is inferred that the plasma Hcy level is mainly correlated with insulin resistance.3. The plasma Hcy level and the plasma MCP-1 were higher in the type 2 diabetes mellitus with macrovascular diseases group compared with the other two groups. The plasma Hcy was significantly positively correlated with plasma MCP-1 (P<0.05) in the type 2 diabetes mellitus with macrovascular diseases group. These indicate that the interaction between elevated plasma Hcy level and MCP-1 might be one of the reasons for the type 2 diabetic macrovascular diseases.