Serum Level Of 5-hydroxytryptamine (5-HT) And Cyclic Guanosine Monophosphate (CGMP) And Its Clinical Significance In Patients With Viral Hepatitis B

【Objective】: To further explore the relationship between TypeⅠhypersensitivity reaction and mechanism of the Viral hepatitis B throughthe examination of 5-hydroxytryptamine and Cyclic guanosinemonophosphate (CGMP)levels in serum patients with Viral hepatitis B andnormal people. Provide new theory for the perfection of the immunologicalmechanism of hepatitis B.【Methods】: Serum COMP and 5-HT levels weremeasured in 45 patients with viral hepatitis B and 30 normal cases usingdouble-antibody sandwich ELISA method. Serum ALT and AST levels weremeasured with automatic biochemistry analyzer, and observing itscorrelatition with CGMP and 5-HT.【Results】:①The 5-HT and CGMP levelsof 6 cases acute hepatitis B were significantly higher than the normalcases;②The 5-HT and CGMP levels of 39 cases chronic hepatitis B werealso significantly higher than the normal cases. The levels of the seriouschronic hepatitis B is highest than others and the levels of midrangegroup is higher than the light group.③Serum levels of 5-HT and CGMP inpatients were significantly and positively correlated with serum levelsof ALT and AST.【Conclusions】:①Serum levels of 5-HT and CGMP in patientsviral hepatitis B may reflect the damage of liver.②The examination ofthe serum levels in 5-HT and CGMP may judge the patients' condition andconsult, It has certainly prognosis value.③The result of our previousresearch combined the examination that the serum levels of 5-HT andCGMP. That provided further substantial evidence for the probability ofthe interference of I hypersensitivity reaction with the mechanism ofhepatitis B.