| Objective: Lung cancer is one of the most familiar malignant tumors in the world, The incidence and the mortality of lung cancer increased continuously. Through several decades' clinical and experimental study, TCM can improve the life quality, delay the cancer development, metastasis, and prolong survival time. But because methodologies of TCM clinical research are weak in use, the standardized of clinical trials are less, Clinical effect lack of objective and scientific evaluation, that research results are difficult to be recognized and promoted. Systematic Review recognized in the international medical profession, expanding systematic review facilitate the search for an effective drugs, methods, technology, measures, etc, this can provide constructive comments and promote the development of TCM. The purpose of the article is to use the systematic reviews Meta-analysis to evaluate the clinical effect of the TCM that it helps the NSCLC.Methods: Use the data base to searches literatures during 1995-2006 years. To investigate the clinical effect of TCM that it helps the NSCLC. According to inclusion-creteria and exclusion-creteria filtrate the literatures. Based on the principle and the method of DME, formulat the Systematic Review Table of the treatment article of TCM to the NSCLC. It has made statistic analysis from 9 lines. Such as randomization the balance of groups. The inclusion and exclusion criteria, control, sample size, blind-method, statistics method, objects sdandardization, the effect judgement standardization, etc. Calculate the percentage of all kinds of statesand evaluate the quality. Then utilize the RevMan to procee Meta analysis.Results: I have recalled the literatures about climacteric syndrome therapeusis 1045 pieces in all, only 27 randomized controlled trials in line with the inclusion criteria. The whole randomized quality is rather IowoThere are 14 pieces(51.85%) are randomization perfectly, the Other 13(48.15%) did not mention any specific random; There are 2 pieces(7.40%) referring to random assignment controlled by center for the sealed envelopes, 8 pieces (29.63%)only mentioned the envelope, Other 17 pieces(62.96%) have no description of the random distribution of misprision; All of the literature did not use blind-method. Most of the studies simple statement of the Group as the average age, sex, type of pathology. There are 8 pieces(29.63%)clearly stated the words of "comparance", 1 pieces(3.70%)shows the words of "balanced" and so forth. In diagnostic criteria, there are 13 pieces(48.15%) adopting the TCM diagnosis with Western medicine diagnostic criteria;3 pieces(11.11%) only adopting the TCM diagnosis criteria;22 pieces (81.48%) have a clear, fit into the inclusion-creteria, and with the purpose of Chapter;3 pieces(11.11%) in a certain inclusion-creteria, 2 pieces(7.40%)right into the inclusion-creteria description only scattered or description. 13 pieces(48.15%) literature that may affect the authenticity of the main conclusions of mixed-establishment of a reasonable clear inclusion-creteria, 14 pieces(51.85%) without any documentation inclusion-creteria describedo27 pieces all are studying TCM therapies; Evaluate the standardization of experimental medicine, from the Recipe composition, dosage form, dosage, usage, regimen, etc. The better standardization are 3 pieces(11.11%),the good are 13 pieces(48.15%),the general are 9 pieces(33.33%),the poor is 1 pieces(3.70%);There are 27 pieces used chemotherapy as control group. 24 pieces(88.89%)using national institute standards, 3 pieces(11.11%) not describe the efficacy standards. There are 16 pieces(59.26%)correctly using basic methods, 11 pieces (40.74%)not specify the statistical method;8 pieces(29.63%) recorded the adverse events in each group of symptoms and a few cases, and a statistical test;12 pieces(44.44%)recorded the adverse events in each group of symptoms and a few cases, but not statistically test;7 pieces(25.92%) literature did not mention adverse reactions and adverse events. The values of efficiency of TCM therapy (between experiment and control)OR=0.68, 95%CI[0.47, 0.99]; the value of stable rate 0R=1.48,95%CI[1.09,2.03].Conclusion: After the results of the preliminary meta-analysis showed that the treatment group and control group in tumor objective change, the efficiency of between the treatment group and the control group is similar(P=0.05), in the stabilization rate the treatment group is better than the control group (P＜0.05), show that TCM in treating NSCLC has certain effects. Existing research finding does not preclude the treatment group and the control group between the effects may be significant differences in test methodologies for low quality, have yet to stringent design of the sample, multi-center, randomized, placebo-controlled, parallel placebo in clinical trials to be confirmed.
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