A 1: 2 Matching Case-Control Study On The Controllable Influential Factors Of Women's Primary Steoporosis

Objective: to discuss the controllable influential factors of primaryosteoporosis (POP) among women and to provide evidence fordeveloping city community's comprehensive prevention against andtreatment of primary osteoporosis.Methods:1:2 matching case reference study is used and all the cases andreferences come from the community groups selected.Select eight communities by multi-stage cluster sampling at randomin Kaifu and Tianxin district, Changsha City. After enquiry diagnosticand physical examination for the women residents aged over 45, thosewho are excluded of secondary osteoporosis diseases causing diseases orother causes are selected as the objects of this study. Then they wereexamined the mineral density with the dual energy X-ray absorption(DEXA), taking T standard recommended by the World HealthOrganization as the standard of diagnosis. Compare the diagnostic POPpatients and the diagnostic non-POP, clinically and by DEXA.Make a1:2 match according to these two elements: the age (a maximum of 4years of difference) and whether or not they have ended catamenia. Thecases and the references were inquired face to face and questionnaireswere filled up. In the questionnaire, 5 aspects and 40 items wereincluded. The data were analyzed through 1:2 matching monofactorialanalysis,and multifactorial conditional logistic regression analysis. The software used in statistics analysis was SPSS 13.0.Results: For this study, we have got 55 pairs of 1:2 matchingstudying objects. The cases and references can be comparable in thegeneral conditions such as racial group and career.1:2 matching x~2 test, monofactorial analysis shows that knowledgeof primary osteoporosis, frequent taking of bean and bean products,frequent drinking of milk, habit of body-exercising and enough sunshineare the protective factors against POP, while high-salt diet, hobby ofdrinking coffee are the dangerous factors of POP. Through themultifactorial conditional logistic regression analysis and adjusting themixed factors, it shows that knowledge of POP(O(?)=0.317, OR95%CI:0.140-0.915), frequent adoption of bean and bean products(O(?)=0.326,OR95%CI: 0.118-0.932), habit of body-exercising(O(?)=0.403,OR95%CI: 0.167-0.974) and enough sunshine(O(?)=0.508, OR95%CI:0.271-0.951)are protective factors, while hobby of drinkingcoffee(O(?)=2.974, OR95%CI: 1.123-7.877), high-salt diet(O(?)=3.239,OR95%CI: 1.231-8.521) are dangerous factors.Conclusion: Improving the communities' knowledge of POP bypopularizing the related health knowledge of it, more taking in bean andbean products, frequent drinking of milk ,doing more out-doorbody-exercise, taking less coffee and controlling high-salt diet areimportant measures for community groups to prevent POP.