| Objective: To study the clinical significance of serum pepsinogen (PG) subtypes detection for the diagnosis of gastric cancer and other gastric diseases.Methods: The concentrations of serum PG I and PG II in those patients with gastric cancer, gastric ulcer and duodenal ulcer were compared with those in the normal control group, which were detected by Enzyme-linked immunosorbent assay (ELISA).Results: Compared with normal control group, the serum PGI and PGI/PGII ratio levels significantly decreased in gastric cancer group, then the PGI and PGII levels significantly increased in gastric ulcer and duodenal ulcer group. The serum PGI and PGII levels in gastric cancer group were lower than those in the gastric ulcer group. The diagnostic sensitivity and specificity of gastric cancer were 46.7% and 97.2% respectively when the concentration of serum PGI≤70ug/L combined with PGI/PGII≤6.Conclusion: Levels of serum pepsinogen subtypes are closely correlated with gastric diseases. Decreasing of PGI and PGI/PGII ratio levels is a risk factor for gastric cancer, which can be used as a serologic marker to screen and to help diagnosing gastric cancer. That the serum PGI≤70ug/L combined with PGI/PGII≤6 is the most suitable cut-off value to detect gastric cancer. Serum PGI level is useful in the differential diagnosis of gastric cancer from gastric ulcer. Increasing of PGI and PGII levels is a risk factor for peptic ulcer. Gastric ulcer rarely happens in those people with serum concentration of PGI≤100ug/L or PGII≤10ug/L. Duodenal ulcer rarely happens in those people with serum concentration of PGI≤120ug/L or PGII≤9ug/L.
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