The Relationship Between Area Under The Curve Of Ambulatory Blood Pressure And Atherosclerosis In Essential Hypertension

Objective To describe the relationship between the parameter of the ambulatory blood pressure monitoring(ABPM):area under the curve(AUC)and atherosclerosis of common carotid arteries.Methods 60 untreated essential hypertension subjects(30 were in stage 1,30 were in stage 2) and 30 control subjects were selected.24-hour ambulatory blood pressure monitoring was used to examine area under the curve of ambulatory blood pressure.Intimae media thickness(IMT) of common carotid arteries,diameter and plaque were evaluated by ultrasonography,Intimae media thickness≥1.3mm was defined as plaque.Results area under the curve of systolic blood pressure(including 24h,day time,night time SBP-AUC),area under the curve of diastolic blood pressure(including 24h,day time,night time DBP-AUC),and area under the curve of pulse pressure(including 24h,day time,night time PP-AUC)were obviously increased in essential hypertension subjects than that in control(P＜0.05),and SBP-AUC,PP-AUC were increased significantly in stage 2 than that in stage 1(P＜0.05),but DBP-AUC was no significance in two stages of hypertensive subjects(P＞0.05);IMT were thicker in essential hypertension than that in control(P＜0.05),there was a increased trend for the grade of plaque with the increasing for IMT(P＜0.05).There were positive correlation between SBP-AUC(especially night time SBP-AUC),IMT and the grade of plaque; There were positive correlation between PP-AUC(especially night time PP-AUC),IMT and the grade of plaque.Conclusion AUC were exactly composite two dimensional parameter,there was a increased trend for the degree of atherosclerosis with the increasing for SBP-AUC,and PP-AUC (especially night time SBP-AUC,and PP-AUC).IMT of common carotid arteries was early manifestation of atherosclerosis;atheromatous plaque can be predicted by IMT in essential hypertension subjects.