The Correlative Study Of Protein Z And Acute Ischemic Stroke

[Objective] To discuss the relation between plasma protein Z level,acute ischemic stroke and etiologic subtypes of ischemic stroke.[Methods] We conducted a case-control study of 42 hospital cases ofacute ischemic stroke and 42 randomly selected controls. Plasma proteinZ concentrations were measured within 7 days after acute ischemicstroke(limosis in controls)with ELISA assay. Plasma PT, APTT, FIB andserum OLUCOSE, TG, TC, CRP were measured simultaneity. Using establishedMRI criteria, we classified cases of acute ischemic stroke by twoetiologic subtype: stroke due to large-artery thromboembolism andstroke due to small-artery thromboembolism and lacuna stroke.[Results] Plasma levels of protein Z measured within 7 days of acuteischemic stroke were significantly higher in cases than incontrols(1.66 versus 1.34 mg/L, P＜0.01), there was a remarkablestatistical significance; ilthrough protein Z levels were higher incases of first-ever acute ischemic stroke than recur ischemicstroke, there were no statistical significance (1.75 versus 1.55 mg/L,P＞0.05); There were no sexual differences in cases or in controls(P＞0.05). In cases of acute ischemic stroke, there was a negativecorrelation between age and protein Z levels (r=-0.463, P＜0.01); Compared with stroke due to small-artery thromboembolism andlacuna, plasma levels of protein Z were higher in stroke due to large-artery thromboembolism (1.86 versus 1.44 mg/L, P＜0.05).Serum levels of C-reactive protein were significantly higher in casesthan in controls(7.56 versus2.89 mg/L, P＜0.01), there was a remarkablestatistical significance; Serum levels of TG were significantly higherin cases than in controls(2.16 versus 1.16mmol/L, P＜0.01), there wasa remarkable statistical significance; Serum levels of GLUCOSE werehigher in cases than in controls(7.32 versus 5.32mmol/L, P＜0.05), therewas a statistical significance; Plasma levels of Fibrinogen werehigher in cases than in controls(3.08 versus 2.77g/L, P＜0.05), therewas a statistical significance; There were no statisticalsignificance of plasma PT, APTT and serum TC in cases or in controls.[Conclusions] Plasma levels of protein Z measured within 7 days ofacute ischemic stroke were significantly higher, especially in strokedue to large-artery atherothrombosis. Elevated Plasma levels of proteinZ concentrations might be associated with an increased risk of ischemicstroke especially cerebral ischemia in young.