The Study Of Bystander Effects Of Radiation Brain Injury

Radiation therapy has been admoved in disease of intracalvarium for many years,for example, the postoperation radiotherapy of neurogliocytoma, hypophyseomaand so on. Especially radiotherapy of stereotaxis (X-knife,γ-knife) generallyadmove in various kinds of good and malignant disease in Intracalvarium in recentyears, we generally could meet the appearance of radiation reaction and radiationinjury. At present, the study of bystander effects has been the research hot spot ofradiation biology, but there are no direct report to ionization radiation causedradioactivity brain injury in domestic and overseas academic province. "BystanderEffect", transfer the respond of archaeocyte which get in touch with injury moduledirectly to other cell surrounding which does not get in touch with injury moduleindirectly through the contact of cell and cell-cell communication, then the other cellsurrounding which does not get in touch with injury module indirectly product thesame respond with archaeocyte which get in touch with injury module directly. Since1992 years, Nagasawa etc proposed the the concept of ionising radiation bystandereffect, many researcher overseas has confirmed its existence through many end pointparameter and many advanced detect technology, these verification also get theaffirmation of the sphere of radiation biology. The produce of ionising radiationbystander effect is a challenge to some conventional idea, it could conduce tocomprehend the biological effect of radiation penetratingly, especially the essenceof low dose biological effect of radiation, and it could also to guide the radiationtherapy of tumor in clinic, so the study of radiation brain injury bystander effect isgetting more and more urgent. We have got a lot of research achievement about themechanism of bystander effect which be induced by radiation through our twenty years study, a series of experiments also prove the existence of bystander effect. Theexistence of bystander effect could help we to comprehend the radiate effectiveness oflow does in radiation biology, so we could to make a decision about how to controlthe normal tissue's factor, and we also could better evaluate the disservice of low doseradiation and prevent the after effect of radiation, so the study of bystander effect hasa favourable prospect of application.Our research contains three parts of work., the primary part is to observe theclinical symptom,physical sign,pathology of part which get radiation of radioactiveray and adjacent tissue in radioaction brain injury, the second part is to observe thechanged condition of marrow Polychromatic Erythrocyte Micronucleus andlympholeukocyte's DNA with the technology of single cell gel electrophoresis(SCGE).The three part is to observe the ROS system play a what role in radioaction braininjury.