| Objective: To observe the clinical effects of hydroxycamptothecin on the embolization of cardiac carcinoma. Method: 69 cases with cardiac carcinoma were randomly divided into two groups: Test group and control group. Test group included 33 cases treated with mixture of hydroxycamptothecin and iodine oil, control group included 36 cases with ADM and iodine oil. All the patients were operated with chemotherapy and embolization traps left gastric artery under DSA. To observe recent effects, toxication and side effects and survival condition (postoperative survival rate in 6, 12 and 24month, respectively) . Results: recent effects in test group were 87.9%, were no difference from that of control group(80.6%). Postoperative survival rate of test group were 90.9%,63.6%,and 42.3% in 6, 12, and 24 month respectively, the average survival time was 20.5±4.1 months. And Postoperative survival rate of control group were 86.1%,44.4%,and 16.7%, the average survival time was 15.0±5.3 months. There were remarkably different between the two groups (P<0.05). The postoperative survival time of the patients without metastasis were remarkably different from those with metastasis (P<0.05). The side effects and toxications of two groups were remarkably different (P<0.05). Conclusion: hydroxycamptothecin used in cardiac carcinoma with interventional therapy could reduced the reccurence and transfusion of tumor, remarkably increase the survival rate.
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