Clinical Studies Of Left Ventricular Function Measured By ～(99)Tc～m Sestamibi Gated Myocardial Perfusion SPECT

Gated myocardial perfusion SPECT (GSPECT) can provides much information at one time: myocardium perfusion at stress or at rest, and the whole function and local function of left ventricle, including left ventricular ejection fraction (LVEF), end diastolic volume (EDV), end systolic volume (ESV) and stroke volume (SV), regional wall motion and shortening rate. Consequently GSPECT raise the value of myocardial perfusion scintigraphy, and provide the reliable data for correct clinic judgment of patients'the cardiac condition, choosing treatment protocols, prognosis and assessment of the curative effect.1. Comparison between ⁹⁹Tc^msestamibi gated myocardial perfusion SPECT and echocardiography for assessment of LVEF and left ventricular volumes Objective To evaluate the relationship between LVEF and left ventricular volumes by ⁹⁹Tc^msestamibi gated myocardial perfusion SPECT in comparison with echocardiography.Methods(1)31 patients who underwent both GSPECT and echocardiography within a two weeks period were selected for the study.(2)GSPECT using Emory Cardiac Toolbox Software, whereas echocardiography using biplane Simpson's method, the data including LVEF, EDV, ESV and SV were obtained.(3)The results of GSPECT and echocardiography were compared, and correlation coefficients were analyzed.Results There were good correlations between the two techniques with respect to determinations of LVEF, EDV, ESV, SV(r is separately 0.74,0.87,0.88 and 0.62,all P<0.001), and there was no significant difference between them. Conclusion GSPECT had a good correlation with echocardiography for the measurements of LVEF and left ventricular volumes.2. The effect of Butterworth and Metz reconstruction filters on left ventricular volume and LVEF calculations with ⁹⁹Tc^msestamibi gated myocardial perfusion SPECTObjective This study was carried out to access the differences produced by change of reconstruction filter in measurement of LVEF,EDV,ESV and SV from ⁹⁹Tc^m sestamibi gated myocardial perfusion SPECT studies.Methods(1)46 patients had ⁹⁹Tc^msestamibi gated SPECT myocardial perfusion imaging.(2)The acquired projections were separately filtered with two filters, Butterworth filter and Metz filter. Each study was then further processed to determine LVEF,EDV, ESV and SV by Emory Cardiac Toolbox software.(3)The results of each patient with the two filters were compared,and the correlation coefficients of Butterworth filter and Metz filter were compared. Results The differences between LVEF and ESV were statistically significant. LVEF measured by Butterworth is higher than the one by Metz, while ESV is lower (all P<0.05). There was no significant difference in EDV and SV (all P>0.05). Calculated LVEF, EDV, ESV and SV, for each filter, were well correlated(r is separately 0.95,o.99,0.99 and 0.91,all P<0.001).Conclusion Butterworth filter had a good correlation with Metz filter for the results of left ventricular function with ⁹⁹Tc^msestamibi gated myocardial perfusion SPECT. However the differences between LVEF and ESV were statistically significant. But there was no significant difference between EDV and SV.